Ontology highlight
ABSTRACT:
SUBMITTER: Rached MT
PROVIDER: S-EPMC2798687 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20091214 1
Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. It is unknown, however, how this osteoblast function is regulated transcriptionally. As FoxO1 is a forkhead family transcription factor known to regulate several key aspects of glucose homeostasis, we investigated whether its expression in osteoblasts may contribute to its metabolic functions. Here we show that mice lacking Foxo1 only in osteoblasts had increased pancreatic beta ...[more]