Ontology highlight
ABSTRACT:
SUBMITTER: Barnstable CJ
PROVIDER: S-EPMC2798985 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Journal of ocular biology, diseases, and informatics 20090918 3
Neuronal cell death can be determined by the overall level of reactive oxygen species (ROS) resulting from the combination of extrinsic sources and intrinsic production as a byproduct of oxidative phosphorylation. Key controllers of the intrinsic production of ROS are the mitochondrial uncoupling proteins (UCPs). By allowing a controlled leak of protons across the inner mitochondrial membrane activation of these proteins can decrease ROS and promote cell survival. In both primate models of Parki ...[more]