Ontology highlight
ABSTRACT:
SUBMITTER: Roy SS
PROVIDER: S-EPMC2799216 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Roy Soumya Sinha SS Ehrlich Amy M AM Craigen William J WJ Hajnóczky György G
EMBO reports 20091009 12
Truncated BID (tBID), a proapoptotic BCL2 family protein, induces BAK/BAX-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. The voltage-dependent anion channels (VDACs) are the primary gates for solutes across the outer mitochondrial membrane (OMM); however, their role in apoptotic OMM permeabilization remains controversial. Here, we report that VDAC2(-/-) (V2(-/-)) mouse embryonic fibroblasts (MEFs) are virtually insensitive to ...[more]