Ontology highlight
ABSTRACT:
SUBMITTER: Basan M
PROVIDER: S-EPMC2799988 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Basan Markus M Risler Thomas T Joanny Jean-François JF Sastre-Garau Xavier X Prost Jacques J
HFSP journal 20090320 4
We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed pre ...[more]