A simple method for estimating genetic diversity in large populations from finite sample sizes.

ABSTRACT:

Background

Sample size is one of the critical factors affecting the accuracy of the estimation of population genetic diversity parameters. Small sample sizes often lead to significant errors in determining the allelic richness, which is one of the most important and commonly used estimators of genetic diversity in populations. Correct estimation of allelic richness in natural populations is challenging since they often do not conform to model assumptions. Here, we introduce a simple and robust approach to estimate the genetic diversity in large natural populations based on the empirical data for finite sample sizes.

Results

We developed a non-linear regression model to infer genetic diversity estimates in large natural populations from finite sample sizes. The allelic richne

SUBMITTER: Bashalkhanov S 

PROVIDER: S-EPMC2800116 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature