Ontology highlight
ABSTRACT:
SUBMITTER: Greenman CD
PROVIDER: S-EPMC2800165 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Biostatistics (Oxford, England) 20091015 1
High-throughput oligonucleotide microarrays are commonly employed to investigate genetic disease, including cancer. The algorithms employed to extract genotypes and copy number variation function optimally for diploid genomes usually associated with inherited disease. However, cancer genomes are aneuploid in nature leading to systematic errors when using these techniques. We introduce a preprocessing transformation and hidden Markov model algorithm bespoke to cancer. This produces genotype class ...[more]