Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common adverse event following coronary artery bypass graft surgery. A recent study identified chromosome 4q25 variants associated with AF in ambulatory populations. However, their role in postoperative AF is unknown. We hypothesized that genetic variants in the 4q25 chromosomal region are independently associated with postoperative AF after coronary artery bypass graft surgery.

Methods and results

Two prospectively collected cohorts of patients undergoing coronary artery bypass graft surgery, with or without concurrent valve surgery, at 3 US centers. From a discovery cohort of 959 patients, clinical and genomic multivariate predictors of postoperative AF were identified by genotyping 45 single-nucleotide polymorphisms (SNPs) e

SUBMITTER: Body SC 

PROVIDER: S-EPMC2801871 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature