Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
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ABSTRACT:
SUBMITTER: Belin S
PROVIDER: S-EPMC2802023 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
Belin Stéphane S Kindbeiter Karine K Hacot Sabine S Albaret Marie Alexandra MA Roca-Martinez Jean-Xavier JX Thérizols Gabriel G Grosso Olivier O Diaz Jean-Jacques JJ
RNA (New York, N.Y.) 20091124 1
The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This proce ...[more]
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