Ontology highlight
ABSTRACT:
SUBMITTER: Sherwood TW
PROVIDER: S-EPMC2802056 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Sherwood Thomas W TW Askwith Candice C CC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091101 45
Acid-sensing ion channel 1a (ASIC1a) promotes neuronal damage during pathological acidosis. ASIC1a undergoes a process called steady-state desensitization in which incremental pH reductions desensitize the channel and prevent activation when the threshold for acid-dependent activation is reached. We find that dynorphin A and big dynorphin limit steady-state desensitization of ASIC1a and acid-activated currents in cortical neurons. Dynorphin potentiation of ASIC1a activity is independent of opioi ...[more]