Ontology highlight
ABSTRACT:
SUBMITTER: Bourhis JM
PROVIDER: S-EPMC2802872 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Bourhis Jean Marie JM Vignaud Caroline C Pietrancosta Nicolas N Guéritte Françoise F Guénard Daniel D Lederer Florence F Lindqvist Ylva Y
Acta crystallographica. Section F, Structural biology and crystallization communications 20091127 Pt 12
Glycolate oxidase, a peroxisomal flavoenzyme, generates glyoxylate at the expense of oxygen. When the normal metabolism of glyoxylate is impaired by the mutations that are responsible for the genetic diseases hyperoxaluria types 1 and 2, glyoxylate yields oxalate, which forms insoluble calcium deposits, particularly in the kidneys. Glycolate oxidase could thus be an interesting therapeutic target. The crystal structure of human glycolate oxidase (hGOX) in complex with 4-carboxy-5-[(4-chloropheny ...[more]