Ontology highlight
ABSTRACT:
SUBMITTER: Bougneres L
PROVIDER: S-EPMC2803012 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Immunity 20090801 2
Dendritic cells (DCs) have the striking ability to cross-present exogenous antigens in association with major histocompatibility complex (MHC) class I to CD8(+) T cells. However, the intracellular pathways underlying cross-presentation remain ill defined. Current models involve cytosolic proteolysis of antigens by the proteasome and peptide import into endoplasmic reticulum (ER) or phagosomal lumen by the transporters associated with antigen processing (TAP1 and TAP2). Here, we show that DCs exp ...[more]