Ontology highlight
ABSTRACT:
SUBMITTER: Shulman Z
PROVIDER: S-EPMC2803105 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Shulman Ziv Z Shinder Vera V Klein Eugenia E Grabovsky Valentin V Yeger Orna O Geron Erez E Montresor Alessio A Bolomini-Vittori Matteo M Feigelson Sara W SW Kirchhausen Tomas T Laudanna Carlo C Shakhar Guy G Alon Ronen R
Immunity 20090305 3
Endothelial chemokines are instrumental for integrin-mediated lymphocyte adhesion and transendothelial migration (TEM). By dissecting how chemokines trigger lymphocyte integrins to support shear-resistant motility on and across cytokine-stimulated endothelial barriers, we found a critical role for high-affinity (HA) LFA-1 integrin in lymphocyte crawling on activated endothelium. Endothelial-presented chemokines triggered HA-LFA-1 and adhesive filopodia at numerous submicron dots scattered undern ...[more]