Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent.
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SUBMITTER: Smith EM
PROVIDER: S-EPMC2803324 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
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Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent.
Smith E M EM Wang X X Littrell J J Eckert J J Cole R R Kissebah A H AH Olivier M M
Genomics 20060519 4
The International HapMap Consortium has determined the linkage disequilibrium (LD) patterns of four major human populations. The aim of our investigation was to compare the LD patterns of the HapMap CEPH (Centre d'Etude du Polymorphisme Humain) samples with a family-based cohort of similar ancestry to determine its usefulness as a reference population for disease association studies. We examined four genomic regions on chromosomes 7q, 12p, and 14q totaling 14.3 Mb, initially identified in our li ...[more]
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