Ontology highlight
ABSTRACT:
SUBMITTER: Sowalsky AG
PROVIDER: S-EPMC2803332 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Sowalsky A G AG Alt-Holland A A Shamis Y Y Garlick J A JA Feig L A LA
Oncogene 20091005 1
Ras proteins activate Raf and PI-3 kinases, as well as exchange factors for RalA and RalB GTPases. Many previous studies have reported that the Ral-signaling cascade contributes positively to Ras-mediated oncogenesis. Here, using a bioengineered tissue model of early steps in Ras-induced human squamous cell carcinoma of the skin, we found the opposite. Conversion of Ras-expressing keratinocytes from a premalignant to malignant state induced by decreasing E-cadherin function was associated with a ...[more]