Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
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ABSTRACT:
SUBMITTER: Bem RA
PROVIDER: S-EPMC2803336 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
Bem Reinout A RA van Woensel Job B M JB Lutter Rene R Domachowske Joseph B JB Medema Jan Paul JP Rosenberg Helene F HF Bos Albert P AP
Journal of immunology (Baltimore, Md. : 1950) 20091216 2
Lower respiratory tract infection by the human pneumovirus respiratory syncytial virus is a frequent cause of acute lung injury in children. Severe pneumovirus disease in humans is associated with activation of the granzyme pathway by effector lymphocytes, which may promote pathology by exaggerating proapoptotic caspase activity and proinflammatory activity. The main goal of this study was to determine whether granzymes contribute to the development of acute lung injury in pneumovirus-infected m ...[more]
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