Prevention of steatosis by hepatic JNK1.
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ABSTRACT:
SUBMITTER: Sabio G
PROVIDER: S-EPMC2804105 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Prevention of steatosis by hepatic JNK1.
Sabio Guadalupe G Cavanagh-Kyros Julie J Ko Hwi Jin HJ Jung Dae Young DY Gray Susan S Jun John Y JY Barrett Tamera T Mora Alfonso A Kim Jason K JK Kim Jason K JK Davis Roger J RJ
Cell metabolism 20091201 6
Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in hepatocyte ...[more]
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