Ontology highlight
ABSTRACT:
SUBMITTER: Nishida K
PROVIDER: S-EPMC2804185 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nishida Kazuhiko K Hoshino Mikio M Kawaguchi Yoshiya Y Murakami Fujio F
The Journal of biological chemistry 20091102 1
Ptf1a, a basic helix-loop-helix transcription factor, plays an indispensable role for cell fate specification of subsets of neurons in the developing central nervous system. However, downstream molecules induced by Ptf1a during neural development have not been well characterized. In the present study, we identified immunoglobulin superfamily molecules, Nephrin and Neph3, as direct downstream targets of Ptf1a. First, the expression domains of Nephrin and Neph3 closely resembled those of Ptf1a in ...[more]