Ontology highlight
ABSTRACT:
SUBMITTER: Hoopes JT
PROVIDER: S-EPMC2804372 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Hoopes James T JT Liu Xuying X Xu Xiaomeng X Demeler Borries B Folta-Stogniew Ewa E Li Chris C Ha Ya Y
The Journal of biological chemistry 20091110 3
The amyloid beta-peptide deposit found in the brain tissue of patients with Alzheimer disease is derived from a large heparin-binding protein precursor APP. The biological function of APP and its homologs is not precisely known. Here we report the x-ray structure of the E2 domain of APL-1, an APP homolog in Caenorhabditis elegans, and compare it to the human APP structure. We also describe the structure of APL-1 E2 in complex with sucrose octasulfate, a highly negatively charged disaccharide, wh ...[more]