Quantitative mechanics of endothelial phagocytosis of silicon microparticles.
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ABSTRACT:
SUBMITTER: Serda RE
PROVIDER: S-EPMC2804906 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Quantitative mechanics of endothelial phagocytosis of silicon microparticles.
Serda Rita E RE Gu Jianhua J Burks Jared K JK Ferrari Kim K Ferrari Chiara C Ferrari Mauro M
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20090901 9
Endothelia, once thought of as a barrier to the delivery of therapeutics, is now a major target for tissue-specific drug delivery. Tissue- and disease-specific molecular presentations on endothelial cells provide targets for anchoring or internalizing delivery vectors. Porous silicon delivery vectors are phagocytosed by vascular endothelial cells. The rapidity and efficiency of silicon microparticle uptake lead us to delineate the kinetics of internalization. To discriminate between surface-atta ...[more]
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