Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC2805047 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Gao Shuanhu S Wang Qiaoling Q Huang Lily Jun-Shen LJ Lum Lawrence L Chen Chuo C
Journal of the American Chemical Society 20100101 1
Nakiterpiosin and nakiterpiosinone are two related C-nor-D-homosteroids isolated from the sponge Terpios hoshinota that show promise as anticancer agents. We have previously described the asymmetric synthesis and revision of the relative configuration of nakiterpiosin. We now provide detailed information on the stereochemical analysis that supports our structure revision and the synthesis of the originally proposed and revised nakiterpiosin. In addition, we herein describe a refined approach for ...[more]