Ontology highlight
ABSTRACT:
SUBMITTER: Shakir SM
PROVIDER: S-EPMC2805330 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Shakir Salika M SM Bryant Katie M KM Larabee Jason L JL Hamm Elaine E EE Lovchik Julie J Lyons C Rick CR Ballard Jimmy D JD
Journal of bacteriology 20091113 2
In the current study, we examined the regulatory interactions of a serine/threonine phosphatase (BA-Stp1), serine/threonine kinase (BA-Stk1) pair in Bacillus anthracis. B. anthracis STPK101, a null mutant lacking BA-Stp1 and BA-Stk1, was impaired in its ability to survive within macrophages, and this correlated with an observed reduction in virulence in a mouse model of pulmonary anthrax. Biochemical analyses confirmed that BA-Stp1 is a PP2C phosphatase and dephosphorylates phosphoserine and pho ...[more]