Ontology highlight
ABSTRACT:
SUBMITTER: Welsh P
PROVIDER: S-EPMC2805500 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Welsh Paul P Polisecki Eliana E Robertson Michele M Jahn Sabine S Buckley Brendan M BM de Craen Anton J M AJ Ford Ian I Jukema J Wouter JW Macfarlane Peter W PW Packard Chris J CJ Stott David J DJ Westendorp Rudi G J RG Shepherd James J Hingorani Aroon D AD Smith George Davey GD Schaefer Ernst E Sattar Naveed N
The Journal of clinical endocrinology and metabolism 20091111 1
<h4>Context</h4>Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven.<h4>Objective</h4>The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach.<h4>Methods</h4>In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1 ...[more]