Ontology highlight
ABSTRACT:
SUBMITTER: Chong JL
PROVIDER: S-EPMC2806193 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chong Jean-Leon JL Wenzel Pamela L PL Sáenz-Robles M Teresa MT Nair Vivek V Ferrey Antoney A Hagan John P JP Gomez Yorman M YM Sharma Nidhi N Chen Hui-Zi HZ Ouseph Madhu M Wang Shu-Huei SH Trikha Prashant P Culp Brian B Mezache Louise L Winton Douglas J DJ Sansom Owen J OJ Chen Danian D Bremner Rod R Cantalupo Paul G PG Robinson Michael L ML Pipas James M JM Leone Gustavo G
Nature 20091201 7275
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to enter and progress through S phase. Using a panel of tissue-specific cre-transgenic mice and conditional E2f alleles we examined the effects of E2f1, E2f2 and E2f3 triple deficiency in mu ...[more]