Ontology highlight
ABSTRACT:
SUBMITTER: Taja-Chayeb L
PROVIDER: S-EPMC2806269 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
World journal of surgical oncology 20091217
<h4>Background</h4>Germ-line mutations of the TP53 gene are known to cause Li-Fraumeni syndrome, an autosomal, dominantly inherited, high-penetrance cancer-predisposition syndrome characterized by the occurrence of a variety of cancers, mainly soft tissue sarcomas, adrenocortical carcinoma, leukemia, breast cancer, and brain tumors.<h4>Methods</h4>Mutation analysis was based on Denaturing high performance liquid chromatography (DHPLC) screening of exons 2-11 of the TP53 gene, sequencing, and clo ...[more]