Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women.

ABSTRACT:

Objective

This study aimed to investigate whether polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are associated with age at menarche and age at natural menopause in white women.

Methods

In a cross-sectional study, a total of 305 randomly selected unrelated white women were genotyped for six single nucleotide polymorphisms (SNPs) of the MTHFR gene (including one common replacement, rs1801133). This sample was comprehensively analyzed for the association of the SNPs with age at menarche. Then a subsample of 210 women who experienced natural menopause was analyzed for the association of the MTHFR gene with age at natural menopause.

Results

Duration of breast-feeding was a significant predictor of earlier natural menopause (P < 0.05). No individual

SUBMITTER: Liu P 

PROVIDER: S-EPMC2806497 | biostudies-literature | 2010 Jan-Feb

REPOSITORIES: biostudies-literature