TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.
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ABSTRACT:
SUBMITTER: Koike C
PROVIDER: S-EPMC2806705 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.
Koike Chieko C Obara Takehisa T Uriu Yoshitsugu Y Numata Tomohiro T Sanuki Rikako R Miyata Kentarou K Koyasu Toshiyuki T Ueno Shinji S Funabiki Kazuo K Tani Akiko A Ueda Hiroshi H Kondo Mineo M Mori Yasuo Y Tachibana Masao M Furukawa Takahisa T
Proceedings of the National Academy of Sciences of the United States of America 20091204 1
An essential step in intricate visual processing is the segregation of visual signals into ON and OFF pathways by retinal bipolar cells (BCs). Glutamate released from photoreceptors modulates the photoresponse of ON BCs via metabotropic glutamate receptor 6 (mGluR6) and G protein (Go) that regulates a cation channel. However, the cation channel has not yet been unequivocally identified. Here, we report a mouse TRPM1 long form (TRPM1-L) as the cation channel. We found that TRPM1-L localization is ...[more]
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