Ontology highlight
ABSTRACT:
SUBMITTER: Sato K
PROVIDER: S-EPMC2806738 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Sato Keiko K Naito Mariko M Yukitake Hideharu H Hirakawa Hideki H Shoji Mikio M McBride Mark J MJ Rhodes Ryan G RG Nakayama Koji K
Proceedings of the National Academy of Sciences of the United States of America 20091204 1
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis, but several proteins, including PorT, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (PorK, PorL, PorM, PorN, PorW, and Sov) were similar in sequence to Flavobacte ...[more]