Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
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ABSTRACT:
SUBMITTER: Blankenship AG
PROVIDER: S-EPMC2807181 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Blankenship Aaron G AG Ford Kevin J KJ Johnson Juliette J Seal Rebecca P RP Edwards Robert H RH Copenhagen David R DR Feller Marla B MB
Neuron 20090401 2
In the few days prior to eye-opening in mice, the excitatory drive underlying waves switches from cholinergic to glutamatergic. Here, we describe the unique synaptic and spatiotemporal properties of waves generated by the retina's glutamatergic circuits. First, knockout mice lacking vesicular glutamate transporter type 1 do not have glutamatergic waves, but continue to exhibit cholinergic waves, demonstrating that the two wave-generating circuits are linked. Second, simultaneous outside-out patc ...[more]
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