Ontology highlight
ABSTRACT:
SUBMITTER: Kassavetis GA
PROVIDER: S-EPMC2807326 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20091124 4
The C53 and C37 subunits of RNA polymerase III (pol III) form a subassembly that is required for efficient termination; pol III lacking this subcomplex displays increased processivity of RNA chain elongation. We show that the C53/C37 subcomplex additionally plays a role in formation of the initiation-ready open promoter complex similar to that of the Brf1 N-terminal zinc ribbon domain. In the absence of C53 and C37, the transcription bubble fails to stably propagate to and beyond the transcripti ...[more]