Ontology highlight
ABSTRACT:
SUBMITTER: Gu X
PROVIDER: S-EPMC2807408 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Gu Xiaofeng X Greiner Erin R ER Mishra Rakesh R Kodali Ravindra R Osmand Alex A Finkbeiner Steven S Steffan Joan S JS Thompson Leslie Michels LM Wetzel Ronald R Yang X William XW
Neuron 20091201 6
The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16 mutated to either aspartate (phosphomimetic or SD) or alanine (phosphoresistant or SA). Both mutant proteins preserve the essential function of huntingtin in rescuing knockout mous ...[more]