Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC2807410 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Lu Yongjun Y Ma Xiuying X Sabharwal Rasna R Snitsarev Vladislav V Morgan Donald D Rahmouni Kamal K Drummond Heather A HA Whiteis Carol A CA Costa Vivian V Price Margaret M Benson Christopher C Welsh Michael J MJ Chapleau Mark W MW Abboud François M FM
Neuron 20091201 6
Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex. We found that aortic baroreceptor neurons in the nodose ganglia and their terminals express ASIC2. Conscious ASIC2 null mice developed hypertension, had exaggerated sympathetic and depressed par ...[more]