Ontology highlight
ABSTRACT:
SUBMITTER: Baine M
PROVIDER: S-EPMC2807629 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Baine Michael M Georgie Daniel S DS Shiferraw Elelta Z EZ Nguyen Theresa P T TP Nogaj Luiza A LA Moffet David A DA
Journal of peptide science : an official publication of the European Peptide Society 20090801 8
Increasing evidence suggests that the aggregation of the small peptide Abeta42 plays an important role in the development of Alzheimer's disease. Inhibiting the initial aggregation of Abeta42 may be an effective treatment for preventing, or slowing, the onset of the disease. Using an in vivo screen based on the enzyme EGFP, we have searched through two combinatorially diverse peptide libraries to identify peptides capable of inhibiting Abeta42 aggregation. From this initial screen, three candida ...[more]