Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC2807999 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Du Juan J Martin Sean M SM Levine Mark M Wagner Brett A BA Buettner Garry R GR Wang Sih-han SH Taghiyev Agshin F AF Du Changbin C Knudson Charles M CM Cullen Joseph J JJ
Clinical cancer research : an official journal of the American Association for Cancer Research 20100112 2
<h4>Purpose</h4>Pharmacologic concentrations of ascorbate may be effective in cancer therapeutics. We hypothesized that ascorbate concentrations achievable with i.v. dosing would be cytotoxic in pancreatic cancer for which the 5-year survival is <3%.<h4>Experimental design</h4>Pancreatic cancer cell lines were treated with ascorbate (0, 5, or 10 mmol/L) for 1 hour, then viability and clonogenic survival were determined. Pancreatic tumor cells were delivered s.c. into the flank region of nude mic ...[more]