Ontology highlight
ABSTRACT:
SUBMITTER: Ranatunga S
PROVIDER: S-EPMC2808134 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Ranatunga Sujeewa S Del Valle Juan R JR
Tetrahedron letters 20090501 21
The synthesis of a highly constrained quaternary carbocyclic α-amino acid, (+)-N-Boc-bicycloproline, has been achieved starting from sodium cyclopentadienylide. Key steps include a rhodium-catalyzed nitrenoid C-H insertion to install the tert-alkylamine and a ring-closing metathesis reaction to form the pyrrolidine ring. ...[more]