Ontology highlight
ABSTRACT:
SUBMITTER: Nandurdikar RS
PROVIDER: S-EPMC2808138 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nandurdikar Rahul S RS Maciag Anna E AE Hong Sam Y SY Chakrapani Harinath H Citro Michael L ML Keefer Larry K LK Saavedra Joseph E JE
Organic letters 20100101 1
GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bifunctionalize these PROLI/NO prodrugs, which on activation generate up to 4 mol of NO, a peptide residue, and an N-acetylglucosamine residue. Many of the prodrugs synthesized are efficient sources of intracellular NO. ...[more]