Ontology highlight
ABSTRACT:
SUBMITTER: McWeeney SK
PROVIDER: S-EPMC2808155 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
McWeeney Shannon K SK Pemberton Lucy C LC Loriaux Marc M MM Vartanian Kristina K Willis Stephanie G SG Yochum Gregory G Wilmot Beth B Turpaz Yaron Y Pillai Raji R Druker Brian J BJ Snead Jennifer L JL MacPartlin Mary M O'Brien Stephen G SG Melo Junia V JV Lange Thoralf T Harrington Christina A CA Deininger Michael W N MW
Blood 20091016 2
In chronic-phase chronic myeloid leukemia (CML) patients, the lack of a major cytogenetic response (< 36% Ph(+) metaphases) to imatinib within 12 months indicates failure and mandates a change of therapy. To identify biomarkers predictive of imatinib failure, we performed gene expression array profiling of CD34(+) cells from 2 independent cohorts of imatinib-naive chronic-phase CML patients. The learning set consisted of retrospectively selected patients with a complete cytogenetic response or m ...[more]