Dataset Information

Dynamics of spectro-temporal tuning in primary auditory cortex of the awake ferret.

ABSTRACT: We previously characterized the steady-state spectro-temporal tuning properties of cortical cells with respect to broadband sounds by using sounds with sinusoidal spectro-temporal modulation envelope where spectral density and temporal periodicity were constant over several seconds. However, since speech and other natural sounds have spectro-temporal features that change substantially over milliseconds, we study the dynamics of tuning by using stimuli of constant overall intensity, but alternating between a flat spectro-temporal envelope and a modulated envelope with well defined spectral density and temporal periodicity. This allows us to define the tuning of cortical cells to speech-like and other rapid transitions, on the order of milliseconds, as well as the time evolution of this tuning in response to the appearance of new features in a sound. Responses of 92 cells in AI were analyzed based on the temporal evolution of the following measures of tuning after a rapid transition in the stimulus: center of mass and breadth of tuning; separability and direction selectivity; temporal and spectral asymmetry. We find that tuning center of mass increased in 70% of cells for spectral density and in 68% of cells for temporal periodicity, while roughly half of cells (47%) broadened their tuning, with the other half (53%) sharpening tuning. The majority of cells (73%) were initially not direction selective, as measured by an inseparability index, which had an initial low value that then increased to a higher steady state value. Most cells were characterized by temporal symmetry, while spectral symmetry was initially high and then progressed to low steady-state values (61%). We demonstrate that cortical neurons can be characterized by a lag-dependent modulation transfer function. This characterization, when measured through to steady-state, becomes equivalent to the classical spectro-temporal receptive field.

SUBMITTER: Shechter B

PROVIDER: S-EPMC2808190 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Dynamics of spectro-temporal tuning in primary auditory cortex of the awake ferret.

Shechter B B Dobbins H D HD Marvit P P Depireux D A DA

Hearing research 20090718 1-2

We previously characterized the steady-state spectro-temporal tuning properties of cortical cells with respect to broadband sounds by using sounds with sinusoidal spectro-temporal modulation envelope where spectral density and temporal periodicity were constant over several seconds. However, since speech and other natural sounds have spectro-temporal features that change substantially over milliseconds, we study the dynamics of tuning by using stimuli of constant overall intensity, but alternati ...[more]

PMID: 19619629

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Project description:Neural processing of sounds in the dorsal and ventral streams of the (human) auditory cortex is optimized for analyzing fine-grained temporal and spectral information, respectively. Here we use a Wilson and Cowan firing-rate modeling framework to simulate spectro-temporal processing of sounds in these auditory streams and to investigate the link between neural population activity and behavioral results of psychoacoustic experiments. The proposed model consisted of two core (A1 and R, representing primary areas) and two belt (Slow and Fast, representing rostral and caudal processing respectively) areas, differing in terms of their spectral and temporal response properties. First, we simulated the responses to amplitude modulated (AM) noise and tones. In agreement with electrophysiological results, we observed an area-dependent transition from a temporal (synchronization) to a rate code when moving from low to high modulation rates. Simulated neural responses in a task of amplitude modulation detection suggested that thresholds derived from population responses in core areas closely resembled those of psychoacoustic experiments in human listeners. For tones, simulated modulation threshold functions were found to be dependent on the carrier frequency. Second, we simulated the responses to complex tones with missing fundamental stimuli and found that synchronization of responses in the Fast area accurately encoded pitch, with the strength of synchronization depending on number and order of harmonic components. Finally, using speech stimuli, we showed that the spectral and temporal structure of the speech was reflected in parallel by the modeled areas. The analyses highlighted that the Slow stream coded with high spectral precision the aspects of the speech signal characterized by slow temporal changes (e.g., prosody), while the Fast stream encoded primarily the faster changes (e.g., phonemes, consonants, temporal pitch). Interestingly, the pitch of a speaker was encoded both spatially (i.e., tonotopically) in Slow area and temporally in Fast area. Overall, performed simulations showed that the model is valuable for generating hypotheses on how the different cortical areas/streams may contribute toward behaviorally relevant aspects of auditory processing. The model can be used in combination with physiological models of neurovascular coupling to generate predictions for human functional MRI experiments.

Dataset Information

Dynamics of spectro-temporal tuning in primary auditory cortex of the awake ferret.

Publications

Dynamics of spectro-temporal tuning in primary auditory cortex of the awake ferret.

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