Ontology highlight
ABSTRACT:
SUBMITTER: Hoogenraad CC
PROVIDER: S-EPMC2808209 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Hoogenraad Casper C CC Popa Ioana I Futai Kensuke K Martinez-Sanchez Emma E Wulf Phebe S PS van Vlijmen Thijs T Dortland Bjorn R BR Oorschot Viola V Govers Roland R Monti Maria M Heck Albert J R AJ Sheng Morgan M Klumperman Judith J Rehmann Holger H Jaarsma Dick D Kapitein Lukas C LC van der Sluijs Peter P
PLoS biology 20100119 1
The endosomal pathway in neuronal dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. However, the molecular mechanisms that organize specific endocytic trafficking routes are poorly understood. Here, we identify GRIP-associated protein-1 (GRASP-1) as a neuron-specific effector of Rab4 and key component of the molecular machinery that coordinates recycling endosome maturation in dendrites. We show that GRASP-1 is necessary for AMPA receptor recyc ...[more]