Finding chimeras: a bioinformatics strategy for identification of cross-linked peptides.
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ABSTRACT:
SUBMITTER: Chu F
PROVIDER: S-EPMC2808265 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Finding chimeras: a bioinformatics strategy for identification of cross-linked peptides.
Chu Feixia F Baker Peter R PR Burlingame Alma L AL Chalkley Robert J RJ
Molecular & cellular proteomics : MCP 20091006 1
Chemical cross-linking, followed by identification of the cross-linked residues, is a powerful approach to probe the topologies and interacting surfaces of protein assemblies. In this work, we demonstrate a new bioinformatics approach using multiple program modules within the software package "Protein Prospector" that greatly facilitates the discovery of cross-linked peptides in chemical cross-linking studies. Examples are given for how this approach has been used for defining interfaces in hete ...[more]
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