Ontology highlight
ABSTRACT:
SUBMITTER: Soudet J
PROVIDER: S-EPMC2808361 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Soudet Julien J Gélugne Jean-Paul JP Belhabich-Baumas Kamila K Caizergues-Ferrer Michèle M Mougin Annie A
The EMBO journal 20091105 1
It is generally assumed that, in Saccharomyces cerevisiae, immature 40S ribosomal subunits are not competent for translation initiation. Here, we show by different approaches that, in wild-type conditions, a portion of pre-40S particles (pre-SSU) associate with translating ribosomal complexes. When cytoplasmic 20S pre-rRNA processing is impaired, as in Rio1p- or Nob1p-depleted cells, a large part of pre-SSUs is associated with translating ribosomes complexes. Loading of pre-40S particles onto mR ...[more]