Ontology highlight
ABSTRACT:
SUBMITTER: Sato A
PROVIDER: S-EPMC2808370 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Sato Akira A Yamamoto Hideki H Sakane Hiroshi H Koyama Hirofumi H Kikuchi Akira A
The EMBO journal 20091112 1
Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the specificity of these pathways is not well understood. This study examined whether the internalization of Wnt receptors affects the ability of Wnt5a to regulate its signalling pathways. Wnt5a activated Rac in the beta-catenin-independent pathway, and Frizzled2 (Fz2) and Ror1 or Ror2 were required for this action. Fz2 was internalized through a clathrin-mediated route in response to Wnt5a, and inhibition of cl ...[more]