Ontology highlight
ABSTRACT:
SUBMITTER: Stratigopoulos G
PROVIDER: S-EPMC2808713 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Stratigopoulos George G LeDuc Charles A CA Matsuoka Naoki N Gutman Roee R Rausch Richard R Robertson Scott A SA Myers Martin G MG Chung Wendy K WK Chua Streamson C SC Leibel Rudolph L RL
Obesity (Silver Spring, Md.) 20081106 1
Perturbations in the functional integrity of the leptin axis are obvious candidates for mediation of altered adiposity. In a large number of genetic association studies in humans, the nonconservative LEPR Q223R allele has been inconsistently associated with adiposity. Subtle, long-term effects of such genetic variants can be obscured by effects of the environment and other confounders that render definitive inferences difficult to reach. We directly assessed the biological effects of this varian ...[more]