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Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.

ABSTRACT: A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.

SUBMITTER: Bajaj A

PROVIDER: S-EPMC2810251 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.

Bajaj Avinash A Miranda Oscar R OR Phillips Ronnie R Kim Ik-Bum IB Jerry D Joseph DJ Bunz Uwe H F UH Rotello Vincent M VM

Journal of the American Chemical Society 20100101 3

A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differ ...[more]

PMID: 20039629

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