Integrative predictive model of coronary artery calcification in atherosclerosis.

ABSTRACT:

Background

Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. We present a model of preclinical atherosclerosis based on genetic and clinical data that predicts the presence of coronary artery calcification in healthy Americans of European descent 45 to 84 years of age in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods and results

We assessed 712 individuals for the presence or absence of coronary artery calcification and assessed their genotypes for 2882 single-nucleotide polymorphisms. With the use of these single-nucleotide polymorphisms and relevant clinical data, a Bayesian network that predicts the presence of coronary calcification was constructed. The model contained 13 single-nucleotide polymorphi

SUBMITTER: McGeachie M 

PROVIDER: S-EPMC2810344 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature