Ontology highlight
ABSTRACT:
SUBMITTER: Vilotijevic I
PROVIDER: S-EPMC2810534 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20070801 5842
Selectivity rules in organic chemistry have been inferred largely from nonaqueous environments. In contrast, enzymes operate in water, and the chemical effect of the medium change remains only partially understood. Structural characterization of the "ladder" polyether marine natural products raised a puzzle that persisted for 20 years: Although the stereochemistry of adjacent tetrahydropyran (THP) cycles would seem to arise from a biosynthetic cascade of epoxide-opening reactions, experience in ...[more]