Ontology highlight
ABSTRACT:
SUBMITTER: Krause ME
PROVIDER: S-EPMC2810650 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Krause Mary E ME Glass Amanda M AM Jackson Timothy A TA Laurence Jennifer S JS
Inorganic chemistry 20100101 2
Nickel superoxide dismutase (Ni-SOD) catalyzes the disproportionation of superoxide to molecular oxygen and hydrogen peroxide, but the overall reaction mechanism has yet to be determined. Peptide-based models of the 2N:2S nickel coordination sphere of Ni-SOD have provided some insight into the mechanism of this enzyme. Here we show that the coordination sphere of Ni-SOD can be mimicked using the tripeptide asparagine-cysteine-cysteine (NCC). NCC binds nickel with extremely high affinity at physi ...[more]