Ontology highlight
ABSTRACT:
SUBMITTER: Mandal MN
PROVIDER: S-EPMC2810836 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Mandal Md Nawajes A MN Patlolla Jagan M R JM Zheng Lixin L Agbaga Martin-Paul MP Tran Julie-Thu A JT Wicker Lea L Kasus-Jacobi Anne A Elliott Michael H MH Rao Chinthalapally V CV Anderson Robert E RE
Free radical biology & medicine 20081224 5
Age-related macular degeneration (AMD) is a complex disease that has potential involvement of inflammatory and oxidative stress-related pathways in its pathogenesis. In search of effective therapeutic agents, we tested curcumin, a naturally occurring compound with known anti-inflammatory and antioxidative properties, in a rat model of light-induced retinal degeneration (LIRD) and in retina-derived cell lines. We hypothesized that any compound effective against LIRD, which involves significant ox ...[more]