A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.
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ABSTRACT:
SUBMITTER: Ivanov IP
PROVIDER: S-EPMC2811004 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.
Ivanov Ivaylo P IP Ivanov Ivaylo P IP Atkins John F JF Michael Antony J AJ
Nucleic acids research 20091117 2
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway m ...[more]
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