Ontology highlight
ABSTRACT:
SUBMITTER: Serre D
PROVIDER: S-EPMC2811030 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20091111 2
DNA methylation is an epigenetic modification involved in both normal developmental processes and disease states through the modulation of gene expression and the maintenance of genomic organization. Conventional methods of DNA methylation analysis, such as bisulfite sequencing, methylation sensitive restriction enzyme digestion and array-based detection techniques, have major limitations that impede high-throughput genome-wide analysis. We describe a novel technique, MBD-isolated Genome Sequenc ...[more]