Ontology highlight
ABSTRACT:
SUBMITTER: Kanadia RN
PROVIDER: S-EPMC2811824 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Kanadia Rahul N RN Cepko Constance L CL
Genes & development 20100115 3
During development, multiple cell types within a tissue often arise from a common pool of progenitor cells (PCs). PCs typically expand in number, while simultaneously producing post-mitotic cells (PMCs). This balance is partly regulated by transcription factors that are expressed within PCs, such as the basic helix-loop-helix (bHLH) gene mouse atonal homolog 7 (Math5), which is expressed in retinal PCs. Here we report that alternative splicing (AS) of Math5 serves as another layer of regulation ...[more]